GavaghanCommunications | Science for scientists. Issue 6: 14 - 19.9.10.

Item 1, keywords:
Amyloid beta, glucose
metabolism, brain
cellular dynamics.

Amyloid burden distribution in dementia of Alzheimer's type (DAT) suggests the need for a deeper understanding of glucose metabolic end-to-end pathway and final product outcome, location and fate.

Extending the analyses of the metabolic pathways of glucose metabolism beyond those usually studied in neurochemistry could help to elucidate the pathology of Alzheimers. To reach this suggestion the researchers observed in three dimensions, with millimetre precision, the location of radiotracer tagged amyloid beta plaques in people with dementia of Alzheimer's type, compared those findings with the spatial distribution of aerobic glycolysis and presented closely argued reasoning for the need to link glycolysis outcome with detailed cellular mechanisms of the dynamic brain. The detail might help resolve ambiguity about whether observations associated with patients with dementia of Alzheimer's type are cause or consequence. (published 17.9.10 by Snippets of science.

Based on a paper out of embargo 13.9.10 published in the Proceedings of the National Academy of Sciences. Spatial correlation between brain aerobic glycolysis and amyloid (beta) (A beta) deposition. DOI: 10.1073/pnas.1010461107.

Item 2, keywords:
Normal brain,
aerobic glycolysis.

Brain regions involved in cognitive control, working memory and some parts of the default mode network exhibit elevated aerobic glycolysis.

Function might, argue the authors, give insight into why certain brain regions exhibit elevated or depressed aerobic glycolysis. In particular the role of both anabolic and aerobic glycolysis in supporting redox coupled reactions in synaptic membranes, mitochondria and other brain cells would be good future research targets. Published by Snippets of science 17.9.10.

Based on a paper out of embargo 13.9.10 published in the Proceedings of the National Academy of Sciences. Regional aerobic glycolysis in the human brain. DOI:10.1073/pnas.1010459107.

Item 3, keywords:
RNA alternate
expression analysis.

Headline: Drug and non drug resistant rectal cancer cell lines show differential mRNA expression.
I have prepared no text for this item because of lack of time. But the paper is well worth deciphering.

Read Nature Methods. Alternative expression analysis by RNA sequencing. Out of embargo 12.9.10. DOI:10.1038//NMETH.1503.

Science for scientists
Helen Gavaghan©